{"resourceType":"Parameters","parameter":[{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae012d58a72041f3aba","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c3"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"704","display":"Amitriptyline"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"CYP2C19 Rapid Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA124"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c3","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2C19 *1/*17","display":"CYP2C19 *1/*17"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2621","display":"CYP2C19"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae012d58a72041f3abb","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c3"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"32968","display":"clopidogrel"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"CYP2C19 Rapid Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA124"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c3","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2C19 *1/*17","display":"CYP2C19 *1/*17"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2621","display":"CYP2C19"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae012d58a72041f3abc","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c3"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"2556","display":"Citalopram"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"CYP2C19 Rapid Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA124"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c3","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2C19 *1/*17","display":"CYP2C19 *1/*17"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2621","display":"CYP2C19"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae012d58a72041f3ac2","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c3"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"321988","display":"Escitalopram"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"CYP2C19 Rapid Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA124"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c3","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2C19 *1/*17","display":"CYP2C19 *1/*17"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2621","display":"CYP2C19"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae012d58a72041f3ad0","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c3"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"121243","display":"voriconazole"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"CYP2C19 Rapid Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA124"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c3","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2C19 *1/*17","display":"CYP2C19 *1/*17"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2621","display":"CYP2C19"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91a1","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"2670","display":"Codeine"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91a2","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"42355","display":"Fluvoxamine"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91a3","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"26225","display":"Ondansetron"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91a5","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"32937","display":"Paroxetine"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91a8","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"7531","display":"Nortriptyline"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91a9","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"10324","display":"Tamoxifen"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91aa","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"38400","display":"atomoxetine"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91ab","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"10689","display":"Tramadol"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91ac","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"704","display":"Amitriptyline"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91ad","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"7804","display":"Oxycodone"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}},{"name":"implication","resource":{"resourceType":"Observation","id":"dv-631a4ae712d58a72041f91af","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"therapeutic-implication"}]},"subject":{"reference":"Patient/NB6TK328"},"derivedFrom":[{"reference":"Observation/dv-61ccfd4a072302a0eb2115c6"}],"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"93044-6","display":"Level of evidence"}]},"valueCodeableConcept":{"text":"CPIC Level A"}},{"code":{"coding":[{"system":"http://loinc.org","code":"51963-7","display":"medication-assessed"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"27392","display":"tropisetron"}]}},{"code":{"coding":[{"system":"http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs","code":"predicted-therapeutic-implication","display":"predicted-therapeutic-implication"}]},"valueCodeableConcept":{"text":"Normal Metabolizer"}}],"identifier":[{"system":"https://www.pharmgkb.org","value":"PA128"}]}},{"name":"genotype","resource":{"resourceType":"Observation","id":"dv-61ccfd4a072302a0eb2115c6","meta":{"profile":["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype"]},"status":"final","category":[{"coding":[{"system":"http://terminology.hl7.org/CodeSystem/observation-category","code":"laboratory"}]}],"code":{"coding":[{"system":"http://loinc.org","code":"84413-4","display":"Genotype display name"}]},"valueCodeableConcept":{"coding":[{"system":"https://www.pharmvar.org","code":"CYP2D6 *1/*41","display":"CYP2D6 *1/*41"}]},"subject":{"reference":"Patient/NB6TK328"},"component":[{"code":{"coding":[{"system":"http://loinc.org","code":"48018-6","display":"Gene studied"}]},"valueCodeableConcept":{"coding":[{"system":"http://www.genenames.org/geneId","code":"HGNC:2625","display":"CYP2D6"}]}}]}}]}